Phacoanaphylactic Endophthalmitis: A Rare Cause of Postoperative Intraocular Inflammation.
DOI:
https://doi.org/10.70672/5tn9mv51Keywords:
diabetes mellitus, cataract surgery, phacoanaphylactic endophthalmitis, lensectomy, vitrectomy surgeryAbstract
Phacoanaphylactic endophthalmitis (PE) is an uncommon and rare immune response to retained lens material after cataract surgery. This case involves a 71-year-old diabetic man who developed PE following a complicated cataract surgery with posterior capsule rupture (PCR) and retained lens fragments. The patient initially presented with mild postoperative inflammation, but eventually developed granulomatous uveitis, vitritis, and vasculitis.
The diagnosis was made based on clinical findings and intraoperative evidence of retained lens material during pars plana vitrectomy (PPV) and anterior chamber washout, which led to resolution of inflammation and improvement in vision, though anterior chamber and vitreous chamber tap were not performed. Early recognition and timely surgical intervention are crucial in managing PE, especially in diabetic patients prone to postoperative complications.
References
[1] Phacoanaphylactic endophthalmitis - EyeWiki [Internet]. 2024 Nov 12 [cited 2024 Nov 12]. Available from: https://eyewiki.org/Phacoanaphylactic_Endophthalmitis
[2] Marak GE. Phacoanaphylactic endophthalmitis. Surv Ophthalmol. 1992;36(5):325–39. doi:10.1016/0039-6257(92)90109-7
[3] Sridhar U, Tripathy K. Lens-induced inflammation. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 [cited 2022 Feb 8]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK576439
[4] Kalogeropoulos C, Malamou-Mitsi V, Asproudis I, Psilas K. The contribution of aqueous humor cytology in the differential diagnosis of anterior uvea inflammations. Ocul Immunol Inflamm. 2004;12(3):215–25. doi:10.1080/092739490500165
[5] Rao NA, Nerenberg AV, Foster DJ. Torulopsis Candida (Candida formata) endophthalmitis stimulating Propionibacterium acnes syndrome. Arch Ophthalmol. 1991;109(12):1718–24
[6] Castellanos MJ. Endophthalmitis: background, pathophysiology, epidemiology [Internet]. [cited 2024 Nov 12]. Available from: https://emedicine.medscape.com/article/799431-overview
https[10]
[7] Cheema RA, Al-Mubarak MM, Amin YM, Cheema MA. Role of combined cataract surgery and intravitreal bevacizumab injection in preventing progression of diabetic retinopathy. Journal of Cataract & Refractive Surgery. 2009 Jan;35(1):18–25.
://emedicine.medscape.com/article/799431-overview
[8] Kim JH, Yoo WS, Kong MG, Han YS, Kim SJ. A case of phacoanaphylactic uveitis presenting as endophthalmitis. J Korean Ophthalmol Soc. 2016;57(9):1480. doi:10.3341/jkos.2016.57.9.1480
[9] Rao S, Murthy S, Geethamala K. An unsuspected case of lens-induced uveitis: a case report. J Clin Ophthalmol Res [Internet]. 2015 [cited 2025 Mar 21];3(2):100. Available from: https://journals.lww.com/jcor/pages/articleviewer.aspx?year=2015&issue=0.020&article=00009&type=Fulltext
[10] Sridhar U, Tripathy K. Lens-induced inflammation [Internet]. StatPearls Publishing; 2023 [cited 2025 Mar 21]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Asian Journal of Medicine & Health Sciences

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Journal of Engineering Technology (JET) is an open-access journal that follows the Creative Commons Attribution-Non-commercial 4.0 International License (CC BY-NC 4.0)



