Endothelial Dysfunction and Pregnancy-Induced Hypertension: A Bibliometric Analysis (2000–2024).
DOI:
https://doi.org/10.70672/a4c8qm80Keywords:
Bibliometrics, Data Visualisation, Endothelial Dysfunction, Hypertension, Pregnancy-Induced, Preeclampsia.Abstract
Background: This bibliometric analysis examines the evolving landscape of research on endothelial dysfunction and pregnancy-induced hypertension (PIH), focusing on trends, influential contributors, and key themes. Endothelial dysfunction in PIH significantly impacts maternal and foetal health, yet gaps remain in understanding its mechanisms and management.
Objective: The study aims to provide a comprehensive overview of over two decades of publications on endothelial dysfunction and PIH to guide future research and clinical practice.
Study design: Data were retrieved from Scopus, covering 397 publications over 25 years. Bibliometric measures, including citation metrics, co-authorship networks, and term co-occurrence maps, were analysed using the Scopus analytics tool and VOSviewer software. Key metrics included total citations, h-index, and term clustering, offering insights into publication trends, influential contributors, and thematic areas.
Results: The analysis revealed an increasing trend in publications, being the United States and China as the most productive countries. Highly cited studies emphasised translational research linking clinical outcomes with mechanistic insights. Author keyword analysis highlighted research priorities including preeclampsia, hypertension, and oxidative stress. Co-occurrence maps revealed strategic and granular perspectives, highlighting angiogenesis, placental ischaemia, and long-term maternal health as critical themes. Limitations include reliance on Scopus data, which may exclude relevant studies indexed elsewhere.
Conclusion: This study uniquely synthesises bibliometric insights to map the progression of endothelial dysfunction and PIH research. It highlights influential contributors, emerging trends, and key gaps, offering valuable guidance for researchers and policymakers. The findings highlight the importance of integrating mechanistic research with clinical applications to improve outcomes for hypertensive disorders in pregnancy.
References
[1]. Barbosa PO, Tanus-Santos JE, Cavalli RD, Bengtsson T, Montenegro MF, Sandrim VC. The Nitrate-Nitrite-Nitric Oxide Pathway: Potential Role in Mitigating Oxidative Stress in Hypertensive Disorders of Pregnancy. Nutrients. 2024 May 14;16(10):1475. https://doi.org/10.3390/nu16101475
[2]. Björkman S, Lilliecreutz C, Bladh M, Strömberg T, Östgren CJ, Mahmoud A, Kafashian A, Bergstrand S, Sederholm Lawesson S. Microvascular dysfunction in women with a history of hypertensive disorders of pregnancy: A population‐based retrospective cohort study. BJOG: An International Journal of Obstetrics & Gynaecology. 2024 Mar;131(4):433-43. https://doi.org/10.1111/1471-0528.17665
[3]. George EM, Granger JP. Endothelin: key mediator of hypertension in preeclampsia. American journal of hypertension. 2011 Sep 1;24(9):964-9. https://doi.org/10.1038/ajh.2011.99
[4]. Sun B, Gunderson EP, Bertolet M, Lopa SH, Bryan SG, Lewis CE, Catov JM. Inflammatory, Metabolic and Endothelial Biomarkers Before and After Pregnancy Complications. American Journal of Epidemiology. 2024 Apr 17:kwae053. https://doi.org/10.1093/aje/kwae053
[5]. Miller HE, Tierney S, Stefanick ML, Mayo JA, Sedan O, Rosas LG, Melbye M, Boyd HA, Stevenson DK, Shaw GM, Winn VD. Vascular health years after a hypertensive disorder of pregnancy: The EPOCH study. American Heart Journal. 2024 Jun 1;272:96-105. https://doi.org/10.1016/j.ahj.2024.03.004
[6]. LaMarca BB, Cockrell K, Sullivan E, Bennett W, Granger JP. Role of endothelin in mediating tumor necrosis factor-induced hypertension in pregnant rats. Hypertension. 2005 Jul 1;46(1):82-6. https://doi.org/10.1161/01.HYP.0000169152.59854.36
[7]. Khan F, Belch JJ, MacLeod M, Mires G. Changes in endothelial function precede the clinical disease in women in whom preeclampsia develops. Hypertension. 2005 Nov 1;46(5):1123-8. https://doi.org/10.1161/01.HYP.0000186328.90667.95
[8]. Hidayah I, Tariq AR, Jamani NA, Maizura MZ. Periodic Assessment of Antenatal and Post Natal Serum Endothelin-1 (ET-1) and Nitric Oxide (NO) Levels in Hypertensive Disorders of Pregnancy (HDP). IIUM Medical Journal Malaysia. 2019 Aug 1;18(2). https://doi.org/10.31436/imjm.v18i2.90
[9]. Sun F, Peers de Nieuwburgh M, Hubinont C, Debiève F, Colson A. Gene therapy in preeclampsia: the dawn of a new era. Hypertension in Pregnancy. 2024 Dec 31;43(1):2358761. https://doi.org/10.1080/10641955.2024.2358761
[10]. Tyrmi JS, Kaartokallio T, Lokki AI, Jääskeläinen T, Kortelainen E, Ruotsalainen S, Karjalainen J, Ripatti S, Kivioja A, Laisk T, Kettunen J. Genetic risk factors associated with preeclampsia and hypertensive disorders of pregnancy. JAMA cardiology. 2023 Jul 1;8(7):674-83. https://doi.org/10.1001/jamacardio.2023.1312
[11]. Wei J, Mo H, Zhang Y, Deng W, Zheng S, Mao H, Ji Y, Jiang H, Zhu Y. Evolutionary trend analysis and knowledge structure mapping of endothelial dysfunction in sepsis: a bibliometrics study. World Journal of Emergency Medicine. 2024;15(5):386. https://doi.org/10.5847/wjem.j.1920-8642.2024.083
[12]. Alam MS, Islam MM. Bibliometric Study of Placenta in Pregnancy-Induced Hypertension. Journal of the Scientific Society. 2022 Sep 1;49(3):298-303. https://doi.org/10.4103/jss.jss_9_22
[13]. Kahraman, E. and Yıldırım, E., 2020. A bibliometric study: Hypertension during pregnancy. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, 22(3), pp.329-340. https://doi.org/10.24938/kutfd.762913
[14]. Shen X, Tao Y, Wang Y, Obore N, Yu H. Research hotspots and thematic trends in the management of pre-eclampsia: a bibliometric analysis from 2000 to 2022. https://doi.org/10.21203/rs.3.rs-3132519/v1
[15]. Köhler T, González-Morales MG, Banks GC, O’Boyle EH, Allen JA, Sinha R, Woo SE, Gulick LM. Supporting robust, rigorous, and reliable reviewing as the cornerstone of our profession: Introducing a competency framework for peer review. Industrial and Organizational Psychology. 2020 Mar;13(1):1-27. https://doi.org/10.1017/iop.2019.121
[16]. Zhou CC, Zhang Y, Irani RA, Zhang H, Mi T, Popek EJ, Hicks MJ, Ramin SM, Kellems RE, Xia Y. Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice. Nature medicine. 2008 Aug;14(8):855-62. https://doi.org/10.1038/nm.1856
[17]. Redman CW, Staff AC. Preeclampsia, biomarkers, syncytiotrophoblast stress, and placental capacity. American journal of obstetrics and gynecology. 2015 Oct 1;213(4):S9-e1. https://doi.org/10.1016/j.ajog.2015.08.003
[18]. Dimitriadis E, Rolnik DL, Zhou W, Estrada-Gutierrez G, Koga K, Francisco RP, Whitehead C, Hyett J, da Silva Costa F, Nicolaides K, Menkhorst E. Pre-eclampsia. Nature reviews Disease primers. 2023 Feb 16;9(1):8. https://doi.org/10.1038/s41572-023-00417-6
[19]. Williams D. Pregnancy: a stress test for life. Current Opinion in Obstetrics and Gynecology. 2003 Dec 1;15(6):465-71. https://doi.org/10.1097/00001703-200312000-00002
[20]. Rodie VA, Freeman DJ, Sattar N, Greer IA. Pre-eclampsia and cardiovascular disease: metabolic syndrome of pregnancy?. Atherosclerosis. 2004 Aug 1;175(2):189-202. https://doi.org/10.1016/j.atherosclerosis.2004.01.038
[21]. Giorgini P, Di Giosia P, Grassi D, Rubenfire M, D Brook R, Ferri C. Air pollution exposure and blood pressure: an updated review of the literature. Current pharmaceutical design. 2016 Jan 1;22(1):28-51. https://doi.org/10.2174/1381612822666151109111712
[22]. Torrens C, Brawley L, Anthony FW, Dance CS, Dunn R, Jackson AA, Poston L, Hanson MA. Folate supplementation during pregnancy improves offspring cardiovascular dysfunction induced by protein restriction. Hypertension. 2006 May 1;47(5):982-7. https://doi.org/10.1161/01.HYP.0000215580.43711.d1
[23]. Brownfoot FC, Hastie R, Hannan NJ, Cannon P, Tuohey L, Parry LJ, Senadheera S, Illanes SE, Tu’uhevaha J, Tong S. Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction. American journal of obstetrics and gynecology. 2016 Mar 1;214(3):356-e1. https://doi.org/10.1016/j.ajog.2015.12.019
[24]. Chen YH, Chang YC, Wu WJ, Chen M, Yen CC, Lan YW, Cheng HC, Chen CM. Kefir peptides mitigate L-NAME-induced preeclampsia in rats through modulating hypertension and endothelial dysfunction. Biomedicine & Pharmacotherapy. 2024 Nov 1;180:117592. https://doi.org/10.1016/j.biopha.2024.117592
[25]. Chung Ming CL, Pienaar D, Ghorbanpour S, Chen H, Roberts LM, Cole L, McGrath KC, Padula MP, Henry A, Gentile C, McClements L. 3D in vitro modelling of post-partum cardiovascular health reveals unique characteristics and signatures following hypertensive disorders in pregnancy. Biology of Sex Differences. 2024 Nov 25;15(1):94. https://doi.org/10.1186/s13293-024-00672-6
[26]. Wu Y, Sun T, Medina P, Narasimhan P, Stevenson DK, Von Versen-Höynck F, Armstrong J, Wu JC, Sayed N, Winn VD. A Novel Stem Cell Model to Study Preeclampsia Endothelial Dysfunction. Reproductive Sciences. 2024 Oct;31(10):2993-3003. https://doi.org/10.1007/s43032-024-01590-z
[27]. Kuruvilla S, Bustreo F, Kuo T, Mishra CK, Taylor K, Fogstad H, Gupta GR, Gilmore K, Temmerman M, Thomas J, Rasanathan K. The Global strategy for women’s, children’s and adolescents’ health (2016–2030): a roadmap based on evidence and country experience. Bulletin of the World Health Organization. 2016 May 2;94(5):398. https://doi.org/10.2471/BLT.16.170431
[28]. Chuaiphichai S, Dickinson Y, Whiteman CA, Au-Yeung D, McNeill E, Channon KM, Douglas G. Endothelial cell vasodilator dysfunction mediates progressive pregnancy-induced hypertension in endothelial cell tetrahydrobiopterin deficient mice. Vascular Pharmacology. 2023 Jun 1;150:107168. https://doi.org/10.1016/j.vph.2023.107168
[29]. Rodrigues SD, da Silva ML, Martins LZ, Gomes SE, Mariani NA, Silva EJ, Kushima H, Mattos BR, Rizzi E, Dias-Junior CA. Pregnancy hypertension-associated endothelial dysfunction is attenuated by isoflurane anesthesia: Evidence of protective effect related to increases in nitric oxide. Life Sciences. 2023 Oct 15;331:122039. https://doi.org/10.1016/j.lfs.2023.122039
[30]. Vangrieken P, Al-Nasiry S, Remels AH, Schiffers PM, Janssen E, Nass S, Scheijen JL, Spaanderman ME, Schalkwijk CG. Placental Methylglyoxal in Preeclampsia: Vascular and Biomarker Implications. Hypertension. 2024 Jul;81(7):1537-49. https://doi.org/10.1161/HYPERTENSIONAHA.123.22633
[31]. Yadav P, Mishra JS, Hurt MW, Chen DB, Kumar S. H2S donor GYY4137 mitigates sFlt-1-induced hypertension and vascular dysfunction in pregnant rats. Biology of Reproduction. 2024 Oct;111(4):879-89. https://doi.org/10.1093/biolre/ioae103
[32]. Song R, Yadav P, Dangudubiyyam SV, Hofmann A, Mishra JS, Kumar S. Gestational intermittent hypoxia induces endothelial dysfunction and hypertension in pregnant rats: role of endothelin type B receptor. Biology of Reproduction. 2024 Jan;110(1):185-97. https://doi.org/10.1093/biolre/ioad139
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Asian Journal of Medicine & Health Sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Journal of Engineering Technology (JET) is an open-access journal that follows the Creative Commons Attribution-Non-commercial 4.0 International License (CC BY-NC 4.0)
