Formulation of Hydrogel Containing Oenanthe Javanica Extract for Topical Use: Extraction, Formulation and Characterization.
DOI:
https://doi.org/10.70672/f0b31n40Keywords:
Formulation, Hydrogel, Oenanthe Javanica, Topical, Anti-agingAbstract
Human skin is exposed to aging factors such as sun exposure and environmental pollutants, which cause unwanted stress on the skin, primarily due to the generation of reactive oxygen species (ROS) within the skin. Antioxidants can slow down, prevent or reverse aging by neutralizing the free radicals produced by ROS. Oenanthe Javanica (O. javanica) extract carries a potential in the treatment of skin aging due to its high antioxidants content. O. javanica extract (0.8%) was incorporated into a hydrogel carrier at different formulation compositions (A1, A2, A3 and A4). Throughout a 30-day stability study, all formulations were found to maintain optimum pH value within the range of 4.5 to 5.5. No significant changes in the physical appearance of the hydrogel containing extract were observed. Sufficient preservative was added to the hydrogel, and no microbial growth was observed on nutrient agar plates after storage under optimal conditions for microbial growth. As for the smoothness evaluation, 9 out of 10 volunteers preferred and were most satisfied with A4 formulation. All formulations were found to be denser than water, ranging between 24.24 and 26.94. Significantly, the percentage of moisture loss was found to be between 89.77 to 90.33%, indicating all the formulated hydrogels contained high amount of water, providing the moisturizing effect. Rheological analysis demonstrated that the hydrogel exhibited pseudoplastic and shear-thinning behaviour. Thus, the novel formulated hydrogels containing O. javanica extract could open up new possibilities for the production of cosmeceutical products.
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