Amlodipine-induced Generalised Exfoliative Dermatitis: Not to be Missed!
DOI:
https://doi.org/10.70672/m3g1ng63Keywords:
Amlodipine, calcium channel blocker, exfoliative dermatitisAbstract
Amlodipine a calcium channel blocker (CCB), is commonly used in treating hypertension, coronary artery disease, and chronic kidney disease. It is considered a first-line treatment for high blood pressure. Amlodipine acts by selectively inhibiting voltage-gated L-type calcium ion channels, which consequently decreases systemic vascular resistance, total vascular resistance, and muscle contractility. We report a case of amlodipine-induced exfoliative dermatitis, highlighting the importance of recognizing this rare but serious cutaneous reaction to amlodipine, a commonly used drug in primary care. Prompt discontinuation of the offending drug and appropriate management are crucial for improving patient outcomes. Clinicians should maintain a high index of suspicion for drug-induced exfoliative dermatitis in patients presenting with generalized erythema and scaling after initiating new medications.
References
[1].Gruchalla R. Understanding drug allergies. J Allergy Clin Immunol [Internet]. 2000;105(6):637–44.. https://doi.org/10.1016/s0091-6749(00)14352-0
[2].Satoskar RS, Rege N, Bhandarkar SD. Pharmacology and pharmacotherapeutics, 26e. 26th ed. New Delhi, India: Elsevier; 2020.
[3].Cheong K, Yew Y, Tey H. Idiopathic Generalized Exfoliative Dermatitis and Association with Antihypertensive Drugs and Statins: A Retrospective Case-Control Study. Dermatology. 2019;235(2):107–11.
[4].Austad SS, Athalye L. Exfoliative Dermatitis (Erythroderma) [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2020. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554568/
[5].Bulsara KG, Cassagnol M. Amlodipine [Internet]. National Library of Medicine. StatPearls Publishing; 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK519508/
[6].Eyerich K, Ring J. Clinical symptomatology of atopic eczema. In: Atopic Dermatitis - Eczema. Cham: Springer International Publishing; 2023. p. 35–80.
[7].Hidayah RMN, Anjani AD, Ramali LM, Suwarsa O, Gunawan H. Exfoliative due to dermatophytosis. The Journal of Infection in Developing Countries. 2021 Mar 7;15(02):306-9. jidc.org
[8].Fares, H., DiNicolantonio, J. J., O’Keefe, J. H., & Lavie, C. J. (2016). Amlodipine in hypertension: a first-line agent with efficacy for improving blood pressure and patient outcomes. Open Heart, 3(2), e000473. https://doi.org/10.1136/openhrt-2016-000473
[9].Ali, A., Mahmoud, S., & Nguyen, J. (2022). Amlodipine-Induced eczematous drug eruption. Consultant. https://doi.org/10.25270/con.2022.02.00002
[10].Odeh M. Exfoliative dermatitis associated with diltiazem. J Toxicol Clin Toxicol. 1997;35(1):101-4. doi: 10.3109/15563659709001174. PMID: 9022661.
[11].Karakayli, G., Beckham, G., Orengo, I., & Rosen, T. (1999, February 1). Exfoliative dermatitis. AAFP.
[12].Khan S, Khan I, Novak M, Regmi A, Difilippo W. The Concomitant Use of Atorvastatin and Amlodipine Leading to Rhabdomyolysis. Cureus. 2018 Jan 3;10(1).dermatitis
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